The liver starts to fail only when more than half of it is damaged. Thus, once a person demonstrates symptoms of liver failure, there is not much liver function left.
Signs and symptoms of liver failure include:
1) Living Donor - This is an option for some patients with end-stage liver disease. This involves removing a segment of liver from a healthy living donor and implanting into a recipient. Both the donor and recipient liver segments will grow to normal size in a few weeks. The donor may be a blood relative, spouse or friend. They will have to undergo extensive medical and psychological evaluations before the transplant procedure.
2) Cadaver in cadaveric liver transplantation - The donor may be a victim of an accident or head injury. The donor’s heart will still be beating, but the brain would have stopped functioning. Such a person is considered legally dead, his or her brain has permanently and irreversibly stopped working. The heart continues to beat because the donor is attached to a respirator. The respirator delivers an adequate supply of oxygen to all vital organs. T this point, the donor is in an intensive - care unit. The identity of a cadaveric donor and circumstances surrounding the person are kept confidential.
Any member of the family, parent, sibling, child, spouse or a volunteer can donate their liver.
The criteria for a liver donation include:
The liver specialist usually suggests this evaluation once he has diagnosed end-stage liver disease. Recipient evaluation is done in three phases and normally takes 5-7 days in hospital.
After evaluation, the patient is either placed on the waiting list for cadaveric donation, or, if there is a willing and blood group matched family donor available, he/she is evaluated for donation and a
transplant is scheduled.
While on the cadaver waiting list, the patient follows up with the Transplant Team until a suitable liver becomes available. If the patient's condition shows signs of deteriorating,
we normally suggest the family to consider living liver donation.
Only blood group cross-matching i.e. ABO compatibility is sufficient.
A person who needs a liver transplant may not qualify for one because of the following reasons:
The first three months after transplant are the most risky for getting such infections as the flu, so patients should follow these precautions:
Anyone with a long-standing (Chronic) or sudden onset (Acute) severe liver disease leading to liver failure needs to be considered for Liver Transplantation.
No, there is Living donor Transplantation, wherein a segment of liver from a healthy living donor is removed and implanted into a recipient. Both donor and recipient liver segment will grow to normal size in few weeks.
The person must be a close relative, aged between 18-55 years, have a matching blood group, and weigh between 50 - 90 kg ( But not fat).
Yes, It is very safe, since the liver has great reserve and regenerates to its original size quickly ( within 2 - 3 months) after a part of it is removed.
The donor suffers from no long-term effects, does not have to take any medication beyond 2-3 weeks and is back to normalcy in a month.
It depends on the patient level of illness and the expertise available at the Centre. It is successful in more than 90% patients.
Yes, but the number of medicines and the doses decrease with passage of time. Most patients are down to a single medicine in 2 - 4 years which needs to be taken life long.
Not True, by 3 - 6 months, the susceptibility to infection diminishes.
There are typically very few dietary restrictions, depending on the patients basic health condition, after the Livet Transplantation.